(Peer-Reviewed) SNHG16 promotes hepatocellular carcinoma development via activating ECM receptor interaction pathway
Qi-Jun Zhang ¹, Da-Zhi Li ², Bing-Yi Lin ², Lei Geng 耿磊 ², Zhe Yang 杨哲 ² ³, Shu-Seng Zheng 郑树森 ² ³
¹ Department of Thyroid Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
中国 杭州 浙江大学附属第一医院甲状腺疾病诊治中心
² NHC Key Laboratory of Combined Multi-organ Transplantation, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
中国 杭州 浙江大学医学院附属第一医院 卫生部多器官联合移植研究重点实验室
³ Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, Zhejiang Shuren University School of Medicine, Hangzhou 310000, China
中国 杭州 浙江树人大学树兰国际医学院 树兰（杭州）医院肝胆胰外科
Background
Accumulating data have suggested that long non-coding RNAs (lncRNAs) play important roles in regulating tumor cell growth. This study was designed to investigate the role of SNHG16 in hep- atocellular carcinoma (HCC).
Methods
SNHG16 expression was detected with real-time polymerase chain reaction (PCR). The cut- off value of SNHG16 for tumor-free survival (TFS) was determined with receiver operating characteristic curve analysis. Small interfering RNA was used to inhibit the expression of SNHG16 in HCC cell lines. The biologic behavior of HCC cell was determined with cell viability assay and Transwell assay in vitro. The potential predictive value of SNHG16 on prognosis was analyzed by Kaplan-Meier curves and Cox proportional hazards regression model.
Results
SNHG16 expression was upregulated in tumor tissues and HCC cell lines. High expression of SNHG16 was associated with tumor recurrence and poor prognosis after surgery. Multivariate analysis revealed that SNHG16 was an independent prognostic factor for poor recurrence-free survival. Moreover, inhibition of SNHG16 in HepG2, Hep3B, and BEL-7402 cells significantly reduced cell invasiveness and proliferation. Mechanistic analyses indicated that the ECM-receptor interaction pathway was remarkably activated by SNHG16.
Conclusions
SNHG16 might be a promising biomarker for predicting tumor recurrence in HCC patients after surgery and a potential therapeutic target for HCC.
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Hanyu Jin, Hao Li, Zhuolin Chen, Liangye Li, Zurui Wang, Kai Zhou, Weijian Hang, Zhipeng Chen, Junfeng Chen, Kai Shen, Jianfeng Wen, Chen Chen, Cunzheng Fan, Zhijun Yan, Feng Wang, Qizhen Sun
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Opto-Electronic Advances
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Xiaotong Li, Yeseul Kim, Youngsun Jeon, Junhwa Seong, Jaekyung Kim, Peng Tang, Shiqi Hu, Harit Keawmuang, Beomha Yang, Dongmin Jeon, Le Dai, Weiyan Li, Xiaodong Cai, Jinhui Shi, Yong-Sang Ryu, Trevon Badloe, Junsuk Rho
Opto-Electronic Advances
2026-07-10
