Year
Month
(Peer-Reviewed) Label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip
Shi Bai ¹, Xueli Ren ², Kotaro Obata ¹, Yoshihiro Ito ², Koji Sugioka ¹
¹ Advanced Laser Processing Research Team, RIKEN Center for Advanced Photonics, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
² Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan
Opto-Electronic Advances, 2022-08-20
Abstract

Surface-enhanced Raman scattering (SERS), owing to its high sensitivity based on localized surface plasmon resonance of nanostructured metals, is recently attracting much attention to be used for biotechnology, such as cell imaging and tumor therapy. On the other hand, the trace detection of bio-molecules with large molecular weight is still challenging because the troublesome treatment of SERS substrate using coupling or cross-linking agents is required.

In this paper, we apply liquid interface assisted SERS (LI-SERS) method, which provides unique features of collection and self-immobilization of analyte molecules on the SERS substrate, to realize the label-free trace detection of bio-molecules with detection limits of pM ~ fM. Specifically, deoxyribonucleic acid (DNA) discrimination and quantitative detection of β-Amyloid (Aβ) in trace-concentration are demonstrated to illustrate the ultrahigh sensitivity and versatility of the LI-SERS method.

The results suggest LI-SERS is promising for the early-stage diagnosis of diseases such as virus infection and Alzheimer's disease.
Label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip_1
Label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip_2
Label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip_3
  • High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor
  • Jie Hu, Weihao Lin, Liyang Shao, Chenlong Xue, Fang Zhao, Dongrui Xiao, Yang Ran, Yue Meng, Panpan He, Zhiguang Yu, Jinna Chen, Perry Ping Shum
  • Opto-Electronic Advances
  • 2024-12-16
  • High performance laser induced plasma assisted ablation by GHz burst mode femtosecond pulses
  • Jingbo Yin, Yulong Zhao, Minghui Hong
  • Opto-Electronic Advances
  • 2024-12-16
  • Sequential harmonic spin–orbit angular momentum generation in nonlinear optical crystals
  • Yutao Tang, Zixian Hu, Junhong Deng, Kingfai Li, Guixin Li
  • Opto-Electronic Advances
  • 2024-12-16
  • Design, setup, and facilitation of the speckle structured illumination endoscopic system
  • Elizabeth Abraham, Zhaowei Liu
  • Opto-Electronic Science
  • 2024-12-13
  • Ultra-high-Q photonic crystal nanobeam cavity for etchless lithium niobate on insulator (LNOI) platform
  • Zhi Jiang, Cizhe Fang, Xu Ran, Yu Gao, Ruiqing Wang, Jianguo Wang, Danyang Yao, Xuetao Gan, Yan Liu, Yue Hao, Genquan Han
  • Opto-Electronic Advances
  • 2024-10-31
  • Advanced biological imaging techniques based on metasurfaces
  • Yongjae Jo, Hyemi Park, Hyeyoung Yoon, Inki Kim
  • Opto-Electronic Advances
  • 2024-10-31
  • Orthogonal matrix of polarization combinations: concept and application to multichannel holographic recording
  • Shujun Zheng, Jiaren Tan, Hongjie Liu, Xiao Lin, Yusuke Saita, Takanori Nomura, Xiaodi Tan
  • Opto-Electronic Advances
  • 2024-10-23
  • Streamlined photonic reservoir computer with augmented memory capabilities
  • Changdi Zhou, Yu Huang, Yigong Yang, Deyu Cai, Pei Zhou, Kuenyao Lau, Nianqiang Li, Xiaofeng Li
  • Opto-Electronic Advances
  • 2024-10-22
  • High-precision multi-focus laser sculpting of microstructured glass
  • Kang Xu, Peilin Huang, Lingyu Huang, Li Yao, Zongyao Li, Jiantao Chen, Li Zhang, Shaolin Xu
  • Opto-Electronic Advances
  • 2024-10-09
  • Multi-physical field null medium: new solutions for the simultaneous control of EM waves and heat flow
  • Sailing He, Ruili Zhang, Junbo Liang
  • Opto-Electronic Advances
  • 2024-09-30
  • Adaptive decentralized AI scheme for signal recognition of distributed sensor systems
  • Shixiong Zhang, Hao Li, Cunzheng Fan, Zhichao Zeng, Chao Xiong, Jie Wu, Zhijun Yan, Deming Liu, Qizhen Sun
  • Opto-Electronic Advances
  • 2024-09-29
  • Data-driven polarimetric approaches fuel computational imaging expansion
  • Sylvain Gigan
  • Opto-Electronic Advances
  • 2024-09-28



  • Metasurface-based nanoprinting: principle, design and advances                                Natural history and cycle threshold values analysis of COVID-19 in Xiamen City, China
    About
    |
    Contact
    |
    Copyright © PubCard