Year
Month
(Peer-Reviewed) Flexibility analysis for continuous ibuprofen manufacturing processes
Wenhui Yang 杨雯惠 ¹, Haoyu Yin ², Zhihong Yuan 袁志宏 ¹, Bingzhen Chen 陈丙珍 ³
¹ State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
中国 北京 清华大学化学工程系 化学工程联合国家重点实验室
² School of Material Science and Engineering, Tsinghua University, Beijing 100084, China
中国 北京 清华大学材料学院
³ Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
中国 北京 清华大学化学工程系
Abstract

Continuous ibuprofen (a widespread used analgesic drug) manufacturing is full of superiorities and is a fertile field both in industry and academia since it can not only effectively treat rheumatic and other chronic and painful diseases, but also shows great potential in dental diseases.

As one of central elements of operability analysis, flexibility analysis is in charge of the quantitative assessment of the capability to guarantee the feasible operation in face of variations on uncertain parameters. In this paper, we focus on the flexibility index calculation for the continuous ibuprofen manufacturing process. We update existing state-of-the-art formulations, which traditionally lead to the max-max-max optimization problem, to approach the calculation of the flexibility index with a favorable manner. Advantages regarding the size of the mathematical model and the computational CPU time of the modified method are examined by four cases.

In addition to identifying the flexibility index without any consideration of control variables, we also investigate the effects of different combinations of control variables on the flexibility property to reveal the benefits from taking recourse actions into account.

Results from systematic investigations are expected to provide a solid basis for the further control system design and optimal operation of continuous ibuprofen manufacturing.
Flexibility analysis for continuous ibuprofen manufacturing processes_1
Flexibility analysis for continuous ibuprofen manufacturing processes_2
Flexibility analysis for continuous ibuprofen manufacturing processes_3
Flexibility analysis for continuous ibuprofen manufacturing processes_4
  • High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor
  • Jie Hu, Weihao Lin, Liyang Shao, Chenlong Xue, Fang Zhao, Dongrui Xiao, Yang Ran, Yue Meng, Panpan He, Zhiguang Yu, Jinna Chen, Perry Ping Shum
  • Opto-Electronic Advances
  • 2024-12-16
  • High performance laser induced plasma assisted ablation by GHz burst mode femtosecond pulses
  • Jingbo Yin, Yulong Zhao, Minghui Hong
  • Opto-Electronic Advances
  • 2024-12-16
  • Sequential harmonic spin–orbit angular momentum generation in nonlinear optical crystals
  • Yutao Tang, Zixian Hu, Junhong Deng, Kingfai Li, Guixin Li
  • Opto-Electronic Advances
  • 2024-12-16
  • Design, setup, and facilitation of the speckle structured illumination endoscopic system
  • Elizabeth Abraham, Zhaowei Liu
  • Opto-Electronic Science
  • 2024-12-13
  • Ultra-high-Q photonic crystal nanobeam cavity for etchless lithium niobate on insulator (LNOI) platform
  • Zhi Jiang, Cizhe Fang, Xu Ran, Yu Gao, Ruiqing Wang, Jianguo Wang, Danyang Yao, Xuetao Gan, Yan Liu, Yue Hao, Genquan Han
  • Opto-Electronic Advances
  • 2024-10-31
  • Advanced biological imaging techniques based on metasurfaces
  • Yongjae Jo, Hyemi Park, Hyeyoung Yoon, Inki Kim
  • Opto-Electronic Advances
  • 2024-10-31
  • Orthogonal matrix of polarization combinations: concept and application to multichannel holographic recording
  • Shujun Zheng, Jiaren Tan, Hongjie Liu, Xiao Lin, Yusuke Saita, Takanori Nomura, Xiaodi Tan
  • Opto-Electronic Advances
  • 2024-10-23
  • Streamlined photonic reservoir computer with augmented memory capabilities
  • Changdi Zhou, Yu Huang, Yigong Yang, Deyu Cai, Pei Zhou, Kuenyao Lau, Nianqiang Li, Xiaofeng Li
  • Opto-Electronic Advances
  • 2024-10-22
  • High-precision multi-focus laser sculpting of microstructured glass
  • Kang Xu, Peilin Huang, Lingyu Huang, Li Yao, Zongyao Li, Jiantao Chen, Li Zhang, Shaolin Xu
  • Opto-Electronic Advances
  • 2024-10-09
  • Multi-physical field null medium: new solutions for the simultaneous control of EM waves and heat flow
  • Sailing He, Ruili Zhang, Junbo Liang
  • Opto-Electronic Advances
  • 2024-09-30
  • Adaptive decentralized AI scheme for signal recognition of distributed sensor systems
  • Shixiong Zhang, Hao Li, Cunzheng Fan, Zhichao Zeng, Chao Xiong, Jie Wu, Zhijun Yan, Deming Liu, Qizhen Sun
  • Opto-Electronic Advances
  • 2024-09-29
  • Data-driven polarimetric approaches fuel computational imaging expansion
  • Sylvain Gigan
  • Opto-Electronic Advances
  • 2024-09-28



  • 3D printing of bioinspired compartmentalized capsular structure for controlled drug release                                Residual-stress relaxation mechanism and model description of 5052H32 Al alloy spun ellipsoidal heads during annealing treatment
    About
    |
    Contact
    |
    Copyright © PubCard