Year
Month
(Peer-Reviewed) Post-ingestion conversion of dietary indoles into anticancer agents
Li Ping Lin ¹ ², Dan Liu 刘丹 ², Jia Cheng Qian ², Liang Wu ², Quan Zhao 赵权 ¹, Ren Xiang Tan 谭仁祥 ¹ ²
¹ State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing 210023, China 南京大学 功能生物分子研究所 医药生物技术国家重点实验室
² State Key Laboratory Cultivation Base for TCM Quality and Efficacy, Nanjing University of Chinese Medicine, Nanjing 210023, China 南京中医药大学 中药品质与效能国家重点实验室培育点
National Science Review, 2021-08-13
Abstract

Human health benefits from consuming cruciferous vegetables that release indole-3-carbinol (I3C), but the in vivo transformation of I3C-related indoles remains underinvestigated. Here we present the post-ingestion conversion of I3C into antitumor agents, 2-(indol-3-ylmethyl)-3,3′-diindolylmethane (LTr1) and 3,3′-diindolylmethane (DIM), by conceptualizing and materializing the reaction flux derailing (RFD) approach as a means of unraveling these stepwise transformations to be non-enzymatic but pH-dependent and gut microbe-sensitive.

In the upper (or acidic) gastrointestine, LTr1 generates through the Michael addition of 3-methyleneindolium (3MI, derived in situ from I3C) to DIM producing from I3C via the formaldehyde-releasing (major) and CO2-liberating (minor) pathways. In the large intestine, 'endogenous' I3C and DIM can form respectively from couplings of formaldehyde with one and two molecules of indole (a tryptophan catabolite). Acid-producing gut bacteria such as Lactobacillus acidophilus facilitate the H+-promotable steps. The work updates the understanding on the merits of I3C consumptions and identifies LTr1 as a drug candidate.
Post-ingestion conversion of dietary indoles into anticancer agents_1
Post-ingestion conversion of dietary indoles into anticancer agents_2
Post-ingestion conversion of dietary indoles into anticancer agents_3
  • On-chip light control of semiconductor optoelectronic devices using integrated metasurfaces
  • Cheng-Long Zheng, Pei-Nan Ni, Yi-Yang Xie, Patrice Genevet
  • Opto-Electronic Advances
  • 2025-01-07
  • Ferroelectric domain engineering of lithium niobate
  • Jackson J. Chakkoria, Aditya Dubey, Arnan Mitchell, Andreas Boes
  • Opto-Electronic Advances
  • 2025-01-03
  • Smart reconfigurable metadevices made of shape memory alloy metamaterials
  • Shiqiang Zhao, Yuancheng Fan, Ruisheng Yang, Zhehao Ye, Fuli Zhang, Chen Wang, Weijia Luo, Yongzheng Wen, Ji Zhou
  • Opto-Electronic Advances
  • 2025-01-03
  • Direct detection with an optimal transfer function: toward the electrical spectral efficiency of coherent homodyne detection
  • Xingfeng Li, Jingchi Li, Xiong Ni, Hudi Liu, Qunbi Zhuge, Haoshuo Chen, William Shieh, Yikai Su
  • Opto-Electronic Science
  • 2024-12-24
  • Enhanced amplified spontaneous emission via splitted strong coupling mode in large-area plasmonic cone lattices
  • Jiazhi Yuan, Jiang Hu, Yan Zheng, Hao Wei, Jiamin Xiao, Yi Wang, Xuchao Zhao, Ye Xiang, Yong Lei, Wenxin Wang
  • Opto-Electronic Science
  • 2024-12-19
  • High-resolution tumor marker detection based on microwave photonics demodulated dual wavelength fiber laser sensor
  • Jie Hu, Weihao Lin, Liyang Shao, Chenlong Xue, Fang Zhao, Dongrui Xiao, Yang Ran, Yue Meng, Panpan He, Zhiguang Yu, Jinna Chen, Perry Ping Shum
  • Opto-Electronic Advances
  • 2024-12-16
  • High performance laser induced plasma assisted ablation by GHz burst mode femtosecond pulses
  • Jingbo Yin, Yulong Zhao, Minghui Hong
  • Opto-Electronic Advances
  • 2024-12-16
  • Sequential harmonic spin–orbit angular momentum generation in nonlinear optical crystals
  • Yutao Tang, Zixian Hu, Junhong Deng, Kingfai Li, Guixin Li
  • Opto-Electronic Advances
  • 2024-12-16
  • Design, setup, and facilitation of the speckle structured illumination endoscopic system
  • Elizabeth Abraham, Zhaowei Liu
  • Opto-Electronic Science
  • 2024-12-13
  • Ultra-high-Q photonic crystal nanobeam cavity for etchless lithium niobate on insulator (LNOI) platform
  • Zhi Jiang, Cizhe Fang, Xu Ran, Yu Gao, Ruiqing Wang, Jianguo Wang, Danyang Yao, Xuetao Gan, Yan Liu, Yue Hao, Genquan Han
  • Opto-Electronic Advances
  • 2024-10-31
  • Advanced biological imaging techniques based on metasurfaces
  • Yongjae Jo, Hyemi Park, Hyeyoung Yoon, Inki Kim
  • Opto-Electronic Advances
  • 2024-10-31
  • Orthogonal matrix of polarization combinations: concept and application to multichannel holographic recording
  • Shujun Zheng, Jiaren Tan, Hongjie Liu, Xiao Lin, Yusuke Saita, Takanori Nomura, Xiaodi Tan
  • Opto-Electronic Advances
  • 2024-10-23



  • Stretchable and self-healable hydrogel artificial skin                                Metagenomic evidence for the coexistence of SARS and H1N1 in patients from 2007-2012 flu seasons
    About
    |
    Contact
    |
    Copyright © PubCard