Year
Month
(Peer-Reviewed) Updates on CRISPR-based gene editing in HIV-1/AIDS therapy
Zhihao Zhang, Wei Hou 侯炜, Shuliang Chen 陈述亮
Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China
中国 武汉 武汉大学基础医学院 医学病毒学研究所
Virologica Sinica, 2021-11-15
Abstract

Although tremendous efforts have been made to prevent and treat HIV-1 infection, HIV-1/AIDS remains a major threat to global human health. The combination antiretroviral therapy (cART), although able to suppress HIV-1 replication, cannot eliminate the proviral DNA integrated into the human genome and thus requires lifelong treatment that may lead to various side effects.

In recent years, clustered regularly interspaced short palindromic repeat (CRISPR)-associated nuclease 9 (Cas9) related gene-editing systems have been developed and designed as effective ways to treat HIV-1 infection. However, new gene-targeting tools derived from or functioning like CRISPR/Cas9, including base editor, prime editing, SHERLOCK, DETECTR, PAC-MAN, ABACAS, pfAGO, have been developed and optimized for pathogens detection and diseases correction.

Here, we summarize recent studies on HIV-1/AIDS gene therapy and provide more gene-editing targets based on studies relating to the molecular mechanism of HIV-1 infection. We also identify the strategies and potential applications of these new gene-editing technologies for HIV-1/AIDS treatment in the future. Moreover, we discuss- the caveats and problems that should be addressed before the clinical use of these versatile CRISPR- based gene targeting tools. Finally, we offer alternative solutions to improve the practice of gene targeting in HIV-1/AIDS gene therapy.
Updates on CRISPR-based gene editing in HIV-1/AIDS therapy_1
Updates on CRISPR-based gene editing in HIV-1/AIDS therapy_2
Updates on CRISPR-based gene editing in HIV-1/AIDS therapy_3
Updates on CRISPR-based gene editing in HIV-1/AIDS therapy_4
  • Three-dimensional multichannel waveguide grating filters
  • Si-Yu Yin, Qi Guo, Shan-Ren Liu, Ju-Wei He, Yong-Sen Yu, Zhen-Nan Tian, Qi-Dai Chen
  • Opto-Electronic Science
  • 2024-08-14
  • Ka-Band metalens antenna empowered by physics-assisted particle swarm optimization (PA-PSO) algorithm
  • Shibin Jiang, Wenjun Deng, Zhanshan Wang, Xinbin Cheng, Din Ping Tsai, Yuzhi Shi, Weiming Zhu
  • Opto-Electronic Science
  • 2024-07-26
  • Complete-basis-reprogrammable coding metasurface for generating dynamically-controlled holograms under arbitrary polarization states
  • Zuntian Chu, Xinqi Cai, Ruichao Zhu, Tonghao Liu, Huiting Sun, Tiefu Li, Yuxiang Jia, Yajuan Han, Shaobo Qu, Jiafu Wang
  • Opto-Electronic Advances
  • 2024-07-26
  • Optical micro/nanofiber enabled tactile sensors and soft actuators: A review
  • Lei Zhang, Yuqi Zhen, Limin Tong
  • Opto-Electronic Science
  • 2024-07-26
  • Soliton microcomb generation by cavity polygon modes
  • Botao Fu, Renhong Gao, Ni Yao, Haisu Zhang, Chuntao Li, Jintian Lin, Min Wang, Lingling Qiao, Ya Cheng
  • Opto-Electronic Advances
  • 2024-07-25
  • Focus control of wide-angle metalens based on digitally encoded metasurface
  • Yi Chen, Simeng Zhang, Ying Tian, Chenxia Li, Wenlong Huang, Yixin Liu, Yongxing Jin, Bo Fang, Zhi Hong, Xufeng Jing
  • Opto-Electronic Advances
  • 2024-07-23
  • Spin-controlled generation of a complete polarization set with randomly-interleaved plasmonic metasurfaces
  • Sören im Sande, Yadong Deng, Sergey I. Bozhevolnyi, Fei Ding
  • Opto-Electronic Advances
  • 2024-07-23
  • An inversely designed integrated spectrometer with reconfigurable performance and ultra-low power consumption
  • Ang Li, Yifan Wu, Chang Wang, Feixia Bao, Zongyin Yang, Shilong Pan
  • Opto-Electronic Advances
  • 2024-07-17
  • OptoGPT: A foundation model for inverse design in optical multilayer thin film structures
  • Taigao Ma, Haozhu Wang, L. Jay Guo
  • Opto-Electronic Advances
  • 2024-07-10
  • Paving continuous heat dissipation pathways for quantum dots in polymer with orange-inspired radially aligned UHMWPE fibers
  • Xuan Yang, Xinfeng Zhang, Tianxu Zhang, Linyi Xiang, Bin Xie, Xiaobing Luo
  • Opto-Electronic Advances
  • 2024-07-05
  • Multiplexed stimulated emission depletion nanoscopy (mSTED) for 5-color live-cell long-term imaging of organelle interactome
  • Yuran Huang, Zhimin Zhang, Wenli Tao, Yunfei Wei, Liang Xu, Wenwen Gong, Jiaqiang Zhou, Liangcai Cao, Yong Liu, Yubing Han, Cuifang Kuang, Xu Liu
  • Opto-Electronic Advances
  • 2024-07-05



  • Study on the dynamic behavior of herringbone gear structure of marine propulsion system powered by double-cylinder turbines                                Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019
    About
    |
    Contact
    |
    Copyright © PubCard